Synthesis and Biological Evaluation of New CRH Analogues
نویسندگان
چکیده
منابع مشابه
Synthesis and Biological Evaluation of New CRH Analogues
A series of 7 new human/rat Corticotropin Releasing Hormone (h/r-CRH) analogues were synthesized. The induced alterations include substitution of Phe at position 12 with D-Phe, Leu at positions 14 and 15 with Aib and Met at positions 21 and 38 with Cys(Et) and Cys(Pr). The analogues were tested regarding their binding affinity to the CRH-1 receptor and their activity which is represented by mea...
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ژورنال
عنوان ژورنال: Bioinorganic Chemistry and Applications
سال: 2010
ISSN: 1565-3633,1687-479X
DOI: 10.1155/2010/252348